Physiology, pharmacology and pathophysiology of the calcium-activated non-selective cation TRPM4 channel
The calcium-activated cation TRPM4 (transient receptor potential melastatin 4) channel is predominantly expressed in cells of the cardiovascular, nervous and immune system, pancreas and kidney. TRPM4 seems to be involved in many calcium-dependent cellular processes, such as control of excitable cell activity, insulin secretion or mast cells degranulation. Several genetic variants in the human gene of TRPM4 were linked to cardiac arrhythmias and conduction disorders in patients (Kruse et al., J Clin Invest, 119(9), 2737-44, 2009; Liu et al., Circ Cardiovasc Genet, 3, 374-85, 2010). Furthermore, TRPM4 has been recently linked to the pathogenesis of multiple sclerosis (Schattling et al., Nat Med, 18(12), 1805-11, 2012).
University of Bern, Department Clinical Research
|Sottas Valentin (Ph.D. Student)
Syam Ninda (Ph.D. Student)
Abriel Hugues (PI)
Amarouch Mohamed-Yassine (Postdoctoral Fellow)
Rougier Jean-Sebastien (Postdoctoral Fellow)