The calcium-activated cation TRPM4 channel is predominantly expressed in cells of the cardiovascular and immune system, pancreas and kidney. TRPM4 seems to be involved in many calcium-dependent cellular processes, such as insulin secretion or mast cells degranulation. There is a strong link between mutated TRPM4 channels and fatal forms of cardiac arrhythmias. Although TRPM4 is a promising drug target for treating cardiac arrhythmias, hypertension, or immunological disorders, its physiologic role in many tissues ist still unclear.
University of Bern, Department Clinical Research
|Abriel Hugues (PI)