Structure, function and pharmacology of Na+/Ca2+ exchangers
In humans, mishandling of cytosolic Ca2+ is often the central cause of both contractile dysfunction and heart arrhythmias that can lead to heart disease, the biggest cause of death in the Western world. Together with the sarcoplasmic reticulum Ca2+ ATPase the Na+/Ca2+ exchanger (NCX) is the dominant Ca2+ efflux mechanism that rapidly ejects large amounts of Ca2+ from the cytosol after the muscle contraction phase. However after a heart attack, NCX likely plays a damaging role as the exchanger operates in reverse mode, which can lead to intracellular Ca2+ overload. Similarly, reverse-mode operation of NCX is also suggested during stroke, hypertension and multiple sclerosis.
University of Basel, Biozentrum, The Center for Molecular Life Sciences
|Stahlberg Henning (PI)
Hilge Mark (Principal Investigator)