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Project Description
Project 1 Transporters as targets for cancer therapy (part A)
Glutamate transporters as therapeutic targets (part B)
Project 2A Function, pharmacology and pathophysiology of TRPC1 channels
Project 2B Physiology, pharmacology and pathophysiology of the calcium-activated non-selective cation TRPM4 channel
Project 2C Structure, function and pharmacology of Na+/Ca2+ exchangers (SLC8/SLC24)
Project 3 Novel sodium/hydrogen exchanger NHA2 - A quest for biological function
Project 4 Structure, function and pharmacology of anoctamines, divalent metal ion transporters and vesicular neurotransmitter transporters
Project 5 Pharmaceutical sciences
Project 6 Vesicular neurotransmitter transporters: glutamate and monoamines
Project 7 Structure and molecular transport mechanisms of selected solute transporters
Project 8 Glucose, urate and myo-inositol transporters
Project 9A Transporters in pathologies during pregnancy, part A
Project 9B Transporters in pathologies during pregnancy, part B
Project 10A Ligand design for TRP channels and glutamate, monoamine, metal ion, vitamin C, nucleobase and myo-inositol transporters
Project 10B Ligand development for the vesicular monoamine transporter VMAT2
Project 10C Development of selective fluorescence- and photoaffinity-labeled ligands for glutamate transporters, members of the TRP channel family and other transport proteins
Project 10D Screening assay development and targeting of the endocannabinoid transporter
Project 11 Structural and mechanistic studies of lipid/drug transporters and their therapeutic relevance
Project 12 Role of canalicular lipid secretion in acquired forms of cholestasis
Project 13 Role of ion transporter TRPV6 and other transporters in bone homeostasis