Membrane proteins fulfill innumerous key functions in all living cells and account for ~30 percent of most proteomes. Two thirds of all known drugs on the market target membrane proteins, thus highlighting their critical importance in human health. In spite of their importance, less than a dozen atomic structures of human polytopic membrane proteins are reported. Clearly, there is an immense need for more structural information on human membranes proteins, and membrane proteins in general to understand their function and molecular mechanisms.
Function in NCCR