Frédéric is especially involved in the Glut9 project.
This project focuses on the physiology of the urate transporter Glut9, hyperuricemia and associated pathologies (including acute renal failure, and Metabolic Syndrome). To that purpose, we have developed unique genetic models (whole-body and tissue-specific knockout of Glut9). These allowed us first to decifer the role of Glut9 in urate homeostasis in mice. Next, using such genetic models along with diet manipulation, we have generated a unique model of controlled hyperuricemia to recapitulate the full range of uricemia found in humans. These "humanized" mice models will provide us with the unique opportunity to study the effect of hyperuricemia on the renal function as well as its role in complex human pathologies such as the Metabolic Syndrome.
As the coordinator of the experimentation facility he may as well be involved to some extent in several other projects.