In her PhD project in Daniel Fuster`s group Christine Deisl is working on a novel sodium/hydrogen exchanger (NHE) named NHA2. NHEs are ubiquitous ion transport proteins that are essential for the regulation of cellular and organellar pH, cell volume and cellular and organellar cation homeostasis.
By immunofluorescence studies of mouse pancreata a prominent expression of NHA2 was detected in β-cells of Langerhans islets as well as in mouse and rat insulinoma cell lines. The aim of her work is to elucidate the role of NHA2 within the endocrine pancreas and to investigate the underlying mechanisms by the use of different in vitro and in vivo models.
Function in NCCR